Berkeley Fluids Seminar

Wednesday, September 14, 2016

3110, Etcheverry Hall, 12:00-13:00

Kirk Hansen (Mechanical Engineering, UC Berkeley)

Fluid mechanics of thrombosis in large-artery flows

Abstract: Thrombosis, or pathological blood clotting, is highly associated with regions of altered hemodynamics such as stenoses, aneurysms, bifurcations, and implants. The nature of this relationship, however, is complex and still somewhat poorly understood. Numerical models provide a valuable investigative tool. In this talk, I will present two of our previous works. In the first, biomechanical fluid-stress-induced platelet activation potential is computed in patient-specific models of abdominal aortic aneurysm disease. This activation potential is modeled using both Lagrangian particle-tracking and Eulerian continuum approaches. Contrary to the hypotheses of previous researchers, we found that biomechanical platelet activation is unlikely to be significant in these flows, implying that transport likely plays a key role. In the second work, we develop a reduced-dimensional surface transport model for high-Schmidt-number near-wall mass transport problems as are commonly found in cardiovascular applications. Using a technique similar to the von Karman momentum integral method, the advection-diffusion equation is reduced to a codimension-one transport equation that is solved on the surface manifold of the blood vessel, significantly reducing computational cost. Asymptotic solutions are developed for the reaction-rate-limited and transport-limited regimes, and results show good comparison to those from the full advection-diffusion equation.

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Acknowledgments

Prof. Graham Fleming (Vice Chancellor for Research, UC Berkeley)

Prof. Eliot Quataert on behalf of The Theoretical Astrophysics Center and the Astronomy Department (UC Berkeley)

Prof. Philip S. Marcus on behalf of the Mechanical Engineering Department (UC Berkeley)

Prof. Michael Manga (Earth and Planetary Science, UC Berkeley)

Prof. Evan Variano (Civil and Environmental Engineering, UC Berkeley)